Discovery of the first magic bullet – Salvarsan In 1904 they successfully prepared a red azo dye they called Trypan Red for the treatment of sleeping sickness. By 1901, with the help of Japanese microbiologist Kiyoshi Shiga, Ehrlich experimented with hundreds of dyes on mice infected with trypanosome, a protozoan parasite that causes sleeping sickness. Although he used the German word zauberkugel in his earlier writings, the first time he introduced the English term "magic bullet" was at a Harben Lecture in London in 1908. It was during his research that he coined the terms " chemotherapy" and "magic bullet". He began testing a number of compounds against different microbes. His institute was convenient as it was adjacent to a dye factory. (Later in 1900, he revised his concept as "receptor theory".) Based on his new theory, he postulated that in order to kill microbes, " wir müssen chemisch zielen lernen" ("we have to learn how to aim chemically"). This led him to propose a new concept called " side-chain theory". But Ehrlich's rationale was that the chemical structure called side chain forms antibodies that bind to toxins (such as pathogens and their products) similarly, chemical dyes such as arsenic compounds could also produce such side chains to kill the same microbes. He was publicly lampooned as an imaginary "Dr Phantasus". Arsenic was an infamous poison, and his attempt was criticised. Here his research focused on testing arsenical dyes for killing microbes. Research on therapeutic properties of dyes Įhrlich joined the Institute of Experimental Therapy ( Institut für experimentelle Therapie) at Frankfurt am Main, Germany, in 1899, becoming the director of its research institute the Georg–Speyer Haus in 1906. This led him to abandon his first idea on magic bullet. But after further research, he realised that antibodies sometimes failed to kill microbes. He speculated that these antibodies act as bullets fired from a gun to target specific microbes. ) From Behring's work, Ehrlich understood that antibodies produced in the blood could attack invading pathogens without any harmful effect on the body. Ehrlich was also nominated for that year. (For that discovery, Bering was the first recipient of the Nobel Prize in Physiology or Medicine in 1901. Behring had been investigating antibacterial agents and discovered a diphtheria antitoxin. In the early 1890s, Paul Ehrlich started to work with Emil Behring, professor of medicine at the University of Marburg. This led to the foundation of the concept of chemotherapy. Įhrlich's discovery of Salvarsan in 1909 for the treatment of syphilis is termed as the first magic bullet. His works were the foundation of immunology, and for his contributions he shared the 1908 Nobel Prize in Physiology or Medicine with Élie Metchnikoff. His continued research to discover the magic bullet resulted in further knowledge of the functions of the body's immune system, and in the development of Salvarsan, the first effective drug for syphilis, in 1909. Įhrlich envisioned that just like a bullet fired from a gun to hit a specific target, there could be a way to specifically target invading microbes. Ehrlich had in mind Carl Maria von Weber's popular 1821 opera Der Freischütz, in which a young hunter is required to hit an impossible target in order to marry his bride. The name itself is a reference to an old German myth about a bullet that cannot miss its target. He named the hypothetical agent as Zauberkugel, and used the English translation "magic bullet" in The Harben Lectures at London. While working at the Institute of Experimental Therapy ( Institut für experimentelle Therapie), Ehrlich formed an idea that it could be possible to kill specific microbes (such as bacteria), which cause diseases in the body, without harming the body itself. The magic bullet is a scientific concept developed by a German Nobel laureate Paul Ehrlich in 1907.
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